High Grade Chloroform is used as an industrial solvent and as an intermediate in the manufacture of polymeric materials. The major use of chloroform today is the production of the refrigerant R-22, commonly used in the air conditioning business. High Grade Chloroform is the chronic exposure to chloroform by inhalation that results in effects on the liver, including hepatitis and jaundice and central nervous system effects, such as depression and irritability.